Acute and Sub Chronic Oral Toxicity Study of Linkus (EMA), Plantain Syrup and Altheash Tablet in Mice. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2018]

Author(s):

1. Saira Bano: Research and Development, Herbion Pakistan (Pvt) Limited, Karachi 74900, Pakistan

2. Sadia Shakeel: Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

3. Shafiquat Hussain: Research and Development, Herbion Pakistan (Pvt) Limited, Karachi 74900, Pakistan

4. Naeem Akhtar: Research and Development, Herbion Pakistan (Pvt) Limited, Karachi 74900, Pakistan

5. Amna Iqbal: Department of Eastern Medicine, Jinnah University for Women, Karachi, Pakistan

6. Faheem Akhtar: Research and Development, Herbion Pakistan (Pvt) Limited, Karachi 74900, Pakistan

7. Khan Usmanghani: Research and Development, Herbion Pakistan (Pvt) Limited, Karachi 74900, Pakistan

8. Amna Iqbal: Department of Eastern Medicine, Jinnah University for Women, Karachi, Pakistan

9. Hina Rehman: Department of Eastern Medicine, Jinnah University for Women, Karachi, Pakistan

Abstract:

Objectives: The present preclinical investigation was conducted with the aim to acknowledge the safety of three polyherbal formulations Linkus syrup (EMA), Plantain syrup and AltheaSH tablet extract by evaluating the acute and sub chronic oral toxicity studies in mice. Methods: To determine acute toxicity mice were given individually the doses of 1 or 5 g/kg orally of Linkus syrup (EMA), Plantain syrup and AltheaSH tablet extract. For executing sub chronic oral toxicity, the formulations were given in doses of 50, 100 and 200 mg/kg of body weight for 28 days period. Results: All three polyherbal formulations under test were not found to be the reason of mortality in animals at the administered doses of 1 or 5 g/kg. Further toxicity signs including loss of hairs, lacrimation, weight reduction, gait, tremors and drowsiness were not detected. Conclusion: The current investigation provided confirmation of good tolerance of formulations under test and lack of harmful effects on the functions of the vital body organs of mice in acute and sub chronic oral toxicity analysis. Future prospects will be the conduction of clinical trials of the formulations as the clinical efficiency is verified in preclinical studies.

Page(s): 40-48

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 6, Issue: 1, Year: 2018

Keywords:

Acute and sub chronic oral toxicity studies , Linkus syrup EMA , AltheaSH tablet extract , Plantain syrup

References:

[1] Möttönen , T., 2002.Delay to institution of therapy and induction of remission using single‐drug or combination-disease‐modifying antirheumatic drug therapy in early rheumatoid arthritis,Arthritis & Rheumatology 46 894 -898

[2] MacLean , C.H., 2000.Quality of care for patients with rheumatoid arthritis,Jama 284 -

[3] Jung, 2015.Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model,BMC Complementary and alternative medicine 15 124 -

[4] Möttönen , T., 1999.Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial,The Lancet 353 1568 -1573

[5] Baecklund , E., 2006.Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis,Arthritis & Rheumatology 54 692 -701

[6] ShielJr,W.C., 2011.,Rheumatoid arthritis (RA) -

[7] Sherman , K.J., 2004.Complementary and alternative medical therapies for chronic low back pain: what treatments are patients willing to try? BMC Complementary and, 4 9 -

[8] Walum , E., 1998.Acute oral toxicity,Environmental health perspectives 106 497 -

[9] Sadia , S., 2015.Evaluation of Acute and SubChronic Oral Toxicity of Entoban: A Polyherbal Drug on Experimental Mice,J. Med. Diagn Meth 4 187 -190

[10] Parra , A.L., .Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts, -

[11] Phytomedicine, 2001., 8 395 -400

[12] Jaffary , S.R.A., 2017.Acute and Sub Chronic Oral Toxicity Studies of Weight Loss Formulation in Experimental Animal Models,RADS Journal of Pharmacy and Pharmaceutical Sciences -

[13] ., 5 08 -12

[14] Farzaei , M.H., 2016.A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine,Journal of Pharmacy and Pharmacology 68 1233 -1248

[15] Claeson , U.P., 2000.Adhatoda vasica: a critical review of ethnopharmacological and toxicological data,Journal of Ethnopharmacology 72 1 -20

[16] Kikuchi , M., 2009.Bibliographical investigation of complementary alternative medicines for osteoarthritis and rheumatoid arthritis,Geriatrics & gerontology international 9 29 -40

Citations

Downloads

Views