The effect of mechanical tension on tririated thymidine incorporation (DNA-synthesis) in fibroblasts. | [Journal of Science and Technology • 1984]

Author(s):

1. G. M. Sheehar: Physiology Department, University of Sind, Jamshoro, Pakistan

2. A. F. Ansari: Biochemistry Department, University of Sind, Jamshoro, Pakistan

3. D. M. Shaikh: Biochemistry Department, University of Sind, Jamshoro, Pakistan

Abstract:

Fibroblasts in conventional cultures (glass or plastic) in monolayer form show the Phenomenon of density dependent inhibition of growth. The same cells grown in the form of "sail" sheets in a type (3 dimensional) substrate nitex are multilayered and confluency did not prevent cell division taking place. Application of mechanical tension in fibroblast sheets has shown the involvement of a mechanical factor in the control of cell cycle, hence stimulates tritiated thymidine incorporation (DNA synthesis) in chick embryo fibroblasts.

Page(s): 23-29

DOI: DOI not available

Published: Journal: Journal of Science and Technology, Volume: 8, Issue: 1--2, Year: 1984

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