Abstract:
The heterocyclic compounds carrying oxygen and nitrogenas donor atoms have many therapeutic activities. Among the heterocyclic compounds, Schiff bases carrying two folded nitrogen known as the azomethine group have been reported against several pharmacological activities such as antifungal, antibacterial, and anticancer activities. Furthermore, research work has been revolutionized toward nanotechnology as a nano drug delivery system, increasing the bioavailability of hydrophobic drugs, protecting the drug from the external environment, as well as controlling and sustaining the release of drugs from the mesh network of natural polymers. Schiff bases and their polymeric nanoparticles were synthesized by the nanoprecipitation techniques and characterized by different techniques. These Schiff bases and their nanoparticles were further investigated by the disc diffusion method and significant compounds were further evaluated by minimum inhibitory concentration against the marketed drug fluconazole. Against Candida tropicalis the HPMC polymer named, HHN3 (16.1±0.11) showed more significant activity as compared to the standard drug Fluconazole (12.33±1.15). it could be said that increased resistance to azoles, particularly fluconazole, as a result of irrational antifungal medication. One of Asia's emerging virulent species is C. tropicalis. It is the most common yeast causing systemic and superficial infections. According to the study, C. tropicalis is responsible for bloodstream and urinary tract infections in hospital patients as well as patients admitted to intensive care units (ICU), particularly in patients who are using catheters frequently, taking broad-spectrum antibiotics, and cancer patients.
Page(s):
186-186
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Antifungal
,
HPMC
,
Schiff bases
,
Polymeric nanoparticles