Thyroid hormones regulate the thermoregulatory mechanisms of the body: review | [Pakistan Journal of Biological Sciences • 2023]

Author(s):

1. Wessam Mansour Filfilan: Department of Biology, AlJamoum University College, Umm al-Qura University,Al-Jamum ,Saudi Arabia

Abstract:

Thyroid hormones (TH) playacritical role in metabolism, energy balance and thermogenesiTsh.e mechanisms whereby thyroid hormone increases heat production have been analyzed with emphasis in more recent developments. Thyroid hormone increases obligatory thermogenesis as aresult of the stimulation of numerous metabolic pathways involved in the development, remodeling and delivery of energyto the tissues. In this section, alterations in primary hyperthyroidism and hypothyroidism will be contrasted with the physiological characteristics of TH-dependentregulation in response tofasting and exposure to cold. The current review will discuss the situation with regard to regional thyroid hormones in the Central Nervous System (CNS) and more specifically, in peripheral cells. When caused by exposure to cold or fasting, local anomalies in the CNS are distinct from peripheral compartments, in contrast to hyperthyroidism and hypothyroidism, which differ when similar changes are observed. Lower hypothalamic TH concentrations are associated with cold exposure, although higher peripheral TH levels. The TH tendenciys reversed by fasting. Primary hypothyroidism and hyperthyroidism impair them. The current study aims to trace the various mechanisms used by the thyroid gland to regulate the body s energy production process.

Page(s): 453-457

DOI: 10.3923/pjbs.2023.453.457

Published: Journal: Pakistan Journal of Biological Sciences, Volume: 26, Issue: 9, Year: 2023

Keywords:

Metabolism , thyroid hormone , Body temperature , Thermoregulation , Energy production

References:

[1] Alvarez-Crespo ,Martinez-Sanchez N.,Diéguez C.,Cannon B.,Nedergaard J.,Lopez M. .2016 .M, RI. , : .

[2] . .Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance. Mol. Metab, 5 : 271-282.

[3] Alexander S.B.,Reeder D.,Hernando D. .2015 .Dermal white adipose tissue: A new component of the thermogenic response. J. Lipid Res., 56 : 2061-2069.

[4] Cannon B.,J. Nedergaard B.,A.C. B.,Silva J.E.,J. Nedergaard B.,Y. B.,Breuer O.,Litjohann D.,Sjoberg S.,Angelin B.,Rudling M.,Diéguez C.,Mittag J.,Lopez M.,Grijota-MNa.Rr C.,Ferng J.,D.J. J.,Beckstead D.J.,Kim H.J.,Fillmore N.,C N.,Gonzalez F.,Ferng J.,Diéguez C.,Rahmouni K.,Nogueiras R.,Lopez M. .2015 .The brain and brown fat. J. Appl. Physiol., 47 : 150-168.

[5] Ackermans M.T.,Kalsbeek A.,Fliers E.,Boelen A.,Lindsund B.,Cannon J.,Nedergaard J. .2019 .At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia areindep eofnUCdP1e. nMotl. Metab., 25 : 20-34.

[6] . Cabral M.,Reynaldo N.E.,Cyr E.A.,Nillni M.,Perello M.,MJ. Obregon R.M.,J. Nedergaard B.,J. Nedergaard B.,Clin B.,M. B.,Hall J.A.,Correa-Medina M.,Ueta C.,Cohen D.E.,Bianco A.C.,F. A.C.,Linderman J.D.,Leonard J.L.,Davis P.J. .2010 .Molecular aspects of thyroid hormone actions. Endocr.Rev., 31 : 139-170.

[7] Christoffolete M.A.,Linardi C.C.G.,Carvalho S.D. .2004 .Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene butfailtoincrease brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes, 53 : 577-584.

[8] Cohen P.,Spiegelman B.M. .2015 .Brown and beige fat: Molecular parts of a thermogenic machine. Diabetes, 64 : 2346-2351.

[9] Fliers E.,Boelen A.,A.S.P. van Trotsenburg A.,E. A.,Korbonits M.,Romijn J.A. .2014 .Central Regulation of the Hypothalamo-Pituitary-Thyroid (Hpt) Axis. ISBN: 9780444596024, : 127-138.

[10] Fliers E.,Kalsbeek A. .2010 .Novel neural pathways for metabolic effects of thyroid hormone. Trends Endocrinol. Metab., 21 : 230-236.

[11] Grigg G.,Nowack J.,Bicudo J.EP.W.,Bal N.C.,Woodward H.N. .2022 .Whole-body endothermy: Ancient, homologous and widespread among the ancestors of mammals, birds and crocodylians. Biol. Rev., 97 : 766-801.

[12] Herrmann B,Harder L.,Oelkrug R.,Chen J.,Gachkar S. .2020 .Central hypothyroidism impairs heart rate stability and prevents thyroid hormone-indcuacrdeidac hypertrophy and pyrexia. Thyroid, 30 : 1205-1216.

[13] Hulbert .2004 .Basal metabolic rate: History, composition, regulation, and usefulness. Physiol. Biochem. Zool, 77 : 869-876.

[14] Kalsbeek A,Yi C.X.,Klieverik L.,Liu J.,Fliers E.,P.J.D. E.,Karger S.,AG S. .2014 .Hormonal Control of Metabolism by the Hypothalamus-Autonomic Nervous System-Liver Axis. ISBN: 978-3-318-02639-9, : 1-28.

[15] Kalsbeek A.,Bruinstroop E.,Yi C.X.,Klieverik L.P.,Fleur S.E la,Fliers E. .2010 .Hypothalamic control of energy metabolism via the autonomic nervous system. , 1212 : 114-129.

[16] Klieverik L.P.,Ackermans M.T.,Serlie M.J. .2009 .Central effects of thyronamines on glucose metabolism in rats. J. Endocrinol., 201 : 377-386.

[17] Klieverik ,Janssen ,Riel E.,Foppen P.H.,Bisschop P.H. .2009 .Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paravenntucrleius ctouthlelaivrer. Proc. Natl. Acad. Sci. USA, 106 : 5966-5971.

[18] Lépez C.V.,Alvarez R.,Nogueiras C.,Diéguez C. .2013 .Energy balance regulation by thyroid hormones at central level. Trends Mol. Med, 19 : 418-427.

[19] .2018 .AMPK vars: The VMH strikes back, return of the PVH. Trends Endocrinol. Metab., 29 : 135-137.

[20] M, .2022 .Hypothalamic AMPK as a possible target for energy balance-related diseases. Trends Pharmacol. Sci., 43 : 546-556.

[21] Lépez M,Tena-Sempere M.,Diéguez C. .2016 .A canonical regulator of whole-body energy balance. Nat. Rev. Endocrinol., 12 : 421-432.

[22] Lépez M,Rodriguez-Cuenca S.,Gonzdlez C.R. .2010 .Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med, 16 : 1001-1008.

[23] Zhang Y.,Proenca R.,Maffei M.,Barone M.,L. M. .1994 .Positional cloning of the mouse obese gene and its human homologue. Nature, 372 : 425-432.

[24] Zhang D.H.,Sieglaff D.H.,Suhand S.D. D.H. .2015 .Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver. J.Endocrinol., 224 : 289-301.

[25] Zhang Y.,Song M.,Feng X.,Zhou Y.,Lu Y. .2015 .Thyroidho-rmsonetdeicremaseusHlMGa-CotAriedunctgase phosphorylation via AMP-activated protein kinase in the liver. J. LipidRes,, 56 : 963-971.

[26] Zhao Z.D.,Yang W.Z.,Gao C.,Zhang X. Fuand W. .2017 .A hypothalamic circuit that controls body temperature. Proc. Natl. Acad. Sci. US, 114 : 2042-2047.

[27] Zhu .2010 .New insights into regulation of lipid metabolism by thyroid hormone. Curr. Opin. Endocrinol. Diabetes Obesity, 17 : 408-413.

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