Venoarterial PCO2 Difference: A Marker of Postoperative Cardiac Output in Children with Congenital Heart Disease | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2009]

Author(s):

1. Muhammad Furqan: Department of Paediatrics, The Aga Khan University Hospital, Karachi, Pakistan

2. Fahad Hashmat: Department of Paediatrics, The Aga Khan University Hospital, Karachi, Pakistan

3. Munir Amanullah: Department of Cardiac Surgery, The Aga Khan University Hospital, Karachi, Pakistan

4. Mansoor Khan: Department of Cardiac Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan

5. Hina K. Durani: Department of Cardiac Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan

6. Anwar-ul-Haque: Department of Paediatrics, The Aga Khan University Hospital, Karachi, Pakistan

Abstract:

Objective: To determine the relationship between venoarterial carbon dioxide gradient (?pCO2) and central venous oxygen saturation (ScvO2) in children after cardiac surgery. Study Design: A cohort study. Place and Duration of Study: The Paediatric cardiac intensive care unit of the Aga Khan University Hospital, Karachi, from June 2006 to May 2007. Methodology: All children admitted in the paediatric cardiac intensive care after complete repair of congenital heart defect using cardiopulmonary bypass were included in the study. Simultaneous arterial and central venous blood gas samples were obtained from a catheter placed in the artery (either radial or femoral) and superior vena cava respectively. Linear regression analysis was performed between ScvO2 and ?pCO2. Results: Fifty seven children aged from 5 days to 14 years were included and 272-paired simultaneous arterial and central venous samples were analyzed. Mean venous pCO2 was 47.82±9.03 mmHg and mean arterial pCO2 was 40.50±9.06 mmHg. One hundred seventy four samples had ScvO2 > 70% with mean ?pCO2 of 5.44±2.55 mmHg and 98 samples had ScvO2 < 70% with mean ?pCO2 of 9.07±3.90 mmHg. With ScvO2 < 70%, 77 samples had ?pCO2 of > 6 mmHg while only 21 samples had ?pCO2 of < 6 mmHg (p < 0.001). On the contrary with ScvO2 > 70%, 71 samples had ?pCO2 of > 6 mmHg and 103 samples had ?pCO2 of < 6 mmHg. Coefficient of correlation (R2) between 0.340 was ScvO2 and ?pCO2. Conclusion: Elevated ?pCO2 is practical and can be utilized as a useful adjunct to low ScvO2 in the assessment of low cardiac output syndrome in children after cardiac surgery.

Page(s): 640-643

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 19, Issue: 10, Year: 2009

Keywords:

paediatric , Cardiac Output , Cardiac Output , Cardiac Output , Cardiac Output , Venoarterial pCO2 difference , Central venous oxygen saturation

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