Toxicity and effect of shikonin and analogs on the blood serum proteins of rabbit. | [Pakistan Journal of Pharmacology • 1986]

Author(s):

1. S. Al-Noori: Biology Department, University Mosul, Mosul, Iraq

2. S. N. H. Naqvi: Biology Department, University Mosul, Mosul, Iraq

3. M. Afzal: Biology Department, University Mosul, Mosul, Iraq

4. K. S. Dauood: Biology Department, University Mosul, Mosul, Iraq

Abstract:

Toxicity (LD50) of four compounds i.e. Shikonin, Shikonin propionate, Shikonin-2-ethyl butyrate and phikonin-thiophene-2-carboxylate was determined as 16.00 mg/kg, 9.75 mgm/kg, 8.5 mgm/kg and 6.0 mgm/kg respectively. Electrophoretic pattern shows 7 protein bands in normal blood serum but they were inhibited by those compounds having CH groups. Band 1 and 2 were inhibited in all the gels, while band 7 was inhibited by the analogs having 0-C"-group but not by shikonin which do not contain this group. Protein bands 3-6 were also disturbed indicating poisoning effect.

Page(s): 43-48

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmacology, Volume: 3, Issue: 1--2, Year: 1986

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