Tobacco induced effects on the offsprings of swiss albino mice. | [Isra Medical Journal • 2012]

Author(s):

1. Zaheer A. Memon: Department of Anatomy, Isra University Hyderabad, Sindh, Pakistan

2. Afroz S. Kazi: Department of Anatomy, Isra University Hyderabad, Sindh, Pakistan

3. Faisal Mughal: Department of Anatomy, Isra University Hyderabad, Sindh, Pakistan

4. Alina Jawad: Department of Anatomy, Isra University Hyderabad, Sindh, Pakistan

5. Sana Arain: Department of Anatomy, Isra University Hyderabad, Sindh, Pakistan

Abstract:

OBJECTIVE: To observe the effects of the use of local chewing tobacco in pregnancy and its effects on the weight of offsprings of mice. MATERIAL & METHODS: 20 female Swiss Albino mice were obtained and mated with male mice. After confirmation of pregnancy they were divided into two groups, group A experimental & B control. Group A was given tobacco 5 % mixed with normal diet ad libitum while group B, control was given normal diet. After birth of offsprings, 20 offsprings (10 male & 10 female) were selected randomly from group A and group B respectively. The weight of each baby mouse (offspring) was noted daily till two weeks. RESULTS: showed a significant decrease in the weight of the offsprings (both sexes) of the experimental group as compared to that of control group in both the initial (at birth) and final weight (at two weeks of age). The mean initial weight of experimental male offsprings was found to be 1.17± 0.03 grams while in control group it was 1.48±0.05 grams. The final weight in experimental male offsprings was 8.61± 0.17 grams and in control group it was 11.47±0.08 grams. In female offsprings the mean initial weight of experimental female offsprings was found to be 1.09± 0.04 grams while in control group it was 1.37±0.05 grams. The final weight in experimental female offsprings was 7.87±0.06 grams, however in control group it was 11.04±0.18 grams. When both groups were compared statistically the difference of weight was found to be significant (p value

Page(s): 112-116

DOI: DOI not available

Published: Journal: Isra Medical Journal, Volume: 4, Issue: 2, Year: 2012

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