The effects of Aminophylline on clinical recovery and bispectral index in patients anesthetized with total intravenous anesthesia. | [Pakistan Journal of Medical Sciences • 2014]

Author(s):

1. Sina Ghaffaripour: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

2. Mohammad Bagher Khosravi: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

3. Ashkan Rahimi: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

4. Mohammad Ali Sahmedini: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

5. Abdolhamid Chohedri: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

6. Hilda Mahmoudi: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

7. Mohammad Reza Kazemi: Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:

Objective: Aminophylline, which is clinically used as a bronchodilator, antagonizes the action of adenosine, so it can be used to shorten the recovery time after general anesthesia. Therefore, we wanted to test the hypothesis that the administration of aminophylline leads to an increase in bispectral index (BIS) and clinical recovery in patients anesthetized with total intravenous anesthesia (TIVA). Methods: Ninety two patients who were scheduled for elective inguinal herniorrhaphy were enrolled in this study. All patients were premedicated with midazolam and morphine. Anesthesia was induced with propofol 2.5 mg /kg and remifentanil 2.5 μg/kg without muscle relaxant. For maintenance of anesthesia we used propofol 100μg/kg/min, remifentanil 0.2μg/kg/min and 100% oxygen with stable BIS readings in the range 40-60. After skin closure, aminophylline 4mg/ kg was given to Group A and an equivalent volume of normal saline to Group P. BIS values, heart rate, blood pressure, oxygen saturation and End tidal CO2 (ETco2) were determined. Time to eye opening, extubation time and response to command were measured. Results: There were no significant differences in SpO2, ETco2 and anesthesia time. Heart rate and systolic blood pressure were found to be statistically higher (pConclusions: Injection of aminophylline at emergence time led to significant increase in BIS and shortening recovery time from anesthesia.

Page(s): 1351-1355

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 30, Issue: 6, Year: 2014

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views