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A new method for the determination of isoniazid (isonicotinic acid hydrazide) by the Weisz ring-oven technique.
Author(s):
1. M. Hanif: Pakistan Council of Scientific and Industrial Research, PCSIR Laboratories, Lahore, Pakistan
2. Sumra Naeem: Pakistan Council of Scientific and Industrial Research, PCSIR Laboratories, Lahore, Pakistan
3. Haider Ali: Pharmacy Department, Punjab University, Lahore, Pakistan
4. Shaukat Ali: F. C. Government College, Lahore, Pakistan
Abstract:
A new method has been described for the determination of isonicotinic acid hydrazide (isoniazid) making use of its reaction with ceric sulphate to give a yellow coloured end-product. Interferences by aspirin, paracetamol and caffeine on this determination have also been studied using the Weisz ring-oven technique. It has been observed that isonicotinic acid hydrazide can be determined within the range of 250.0 ng to 30.0Oug with a maximum error of 9.20 % for 250.0 ng of the substance. It can also be determined in the presence of paracetamol, aspirin and caffeine individually and collectively. The method is well suited to the routine analysis of isoniazid because of its accuracy, sensitivity, precision and convenience.
Page(s): 331-333
DOI: DOI not available
Published: Journal: Pakistan Journal of Scientific and Industrial Research, Volume: 30, Issue: 5, Year: 1987
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