Affect of Seasonal Variation on Bacterial Sepsisand Antibiotic Sensitivity Profile in Neonates | [Pakistan Paediatric Journal • 2019]

Author(s):

1. AMBREEN ARIF: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

2. FARIHA HASAN: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

3. QAMAR ALI KHAN: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

4. Aamer Ali Shah: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

5. Arif Mehmood Khan: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

6. Obaid Ullah: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

7. Aftab Khan: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

8. Muhammad Imran: Pakistan Health Research Council (PHRC), Research Centre, KMC Peshawar, Pakistan

Abstract:

Objectives: This study was designed to find out the affects of seasonal variation on neonatal bacteremia and antibiotic sensitivity profile of isolated bacteria. Study design: Cross sectional Place and Duration: Study was carried out from October 2016-2017 in Khyber Teaching Hospital (KTH) Peshawar. Material and Methods: Blood Samples were collected from Nursery and processed in laboratory. Blood sample was collected from suspected septicemic neonates. Blood culture was performed through standard biological techniques and growth was identified through different biochemical tests. Susceptibility to different antibiotics was done by standard Kirby Bauer method. Data entry and analysis were done through SPSS version 20. Results: Among 176 suspected septicemic neonates;40(22.7%) were found positive for bacterial septicemia. Higher number of suspected neonatal bacteremia cases was observed during winter season i.e. 101(57.4%).Statically significant relationship was established between the seasonal changes and different clinical indication and symptom like abdominal distress, poor feeding, hyperthermia and jaundice. In winters Pseudomonas aeruginosa was the leading cause of bacteremia. Carbapenem and Aminoglycoside were very effective against bacteria. Conclusion: This study determined that seasonal variation can affect not even the prevalence of neonatal bacteremia but also the symptomatic expression of diseases condition.

Page(s): 247-254

DOI: DOI not available

Published: Journal: Pakistan Paediatric Journal, Volume: 43, Issue: 4, Year: 2019

Keywords:

Antibiotic , seasonal variation , Neonatal bacteremia

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