A Study of Prescription Pattern of Anti-Diabetic Drugs and Usage of Teneligliptin for Type II Diabetis Mellitus | [Journal of Pioneering Medical Sciences • 2024]

Author(s):

1. Ranjith Raj: Department of Pharmacology, JSS Medical College,Mysuru,

2. Nagma Firdose: Department of Pharmacology, JSS Medical College,Mysuru,

3. H.L. Kalabharathi: Department of Pharmacology, JSS Medical College,Mysuru,

4. Pushpa V.H.: Department of Pharmacology, JSS Medical College,Mysuru,

5. Priyanka C.A.: Department Pharmacology, Vydehi Medical College,Bangalore,

6. A.M. Satish: Department of Pharmacology, JSS Medical College,Mysuru,

Abstract:

Background: Prescription pattern studies are a tool for assessing the prescribing, dispensing and distribution of medicines. Diabetes mellitus (DM) is a spectrum of metabolic disorders as a consequence of different pathogenic mechanisms resulting in hyperglycemia. A genetic predisposition to develop ß -cell dysfunction synergizes with insulin resistance to lead to type 2 DM. Adequate management of type 2 DM requires institution of non- pharmacological management followed by pharmacological management. Currently trending anti diabetic drugs, Teneligliptin a magic drug which is recently developed oral dipeptidyl-peptidase-4 inhibitor indicated for the management of uncontrolled type 2 diabetes mellitus (T2DM) in adults along with diet and exercise. Methods: This cross-sectional study was conducted in the Department of Pharmacology in collaboration with Department of General Medicine. A total of 518 patients were enrolled in study based on inclusion and exclusion criteria after taking written informed consent. A structured case recording form was used to record demographic details and prescription details. The rationality of prescriptions was assessed using American Diabetes Association guidelines (ADA) 2015. Results: Majority of the patients were prescribed combination therapy (54%) followed by monotherapy (46%). Oral anti-diabetic agents used as monotherapy other than metformin were appropriate. Among the patients receiving combination therapy majority were receiving a fixed dose combination which were appropriate. Among the recent anti- diabetic drug Teneligliptin was the most commonly prescribed drug and Teneligliptin has been found to be well accepted and tolerated, and the safety profile is similar to other dipeptidyl peptidase-4 inhibitors. Teneligliptin was used as monotherapy, add-on to metformin or add-on to metformin plus sulfonylureas combination for better glycaemic control. Conclusion: Upon overall analysis this study indicates that rational prescribing of drugs in tertiary care hospital has to be improved by prescribing current trends, Prescribing drugs from Essential drug list (EDL) and the use of combination therapy was significant. The study of drug prescribing pattern showed that antidiabetic drugs were prescribed according to American Diabetes Association guidelines. The trends in prescribing newer anti diabetic drugs shows the acceptance of teneligliptin and updated skills in physicians to promote better glycaemic control.

Page(s): 74-78

DOI: 10.61091/jpms202413513

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 13, Issue: 5, Year: 2024

Keywords:

Diabetes mellitus , Diabetes mellitus , prescription pattern , teneligliptin , oral antidiabetic agents

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