The relationship between polycystic ovary syndrome and serum periostin level | Journal of College of Physicians and Surgeons--Pakistan : JCPSP 2021

Author(s)

Gulsum Gonulalan Department of Endocrinology and Metabolism, School of Medicine, KTO Karatay University, Konya, Turkey

Ibrahim Guney Department of Nephrology, Health Science University, Konya Research and Training Hospital, Konya, Turkey

Fatih Sackan Department of Internal Medicine, Health Science University, Konya Research and Training Hospital, Konya, Turkey

Saadet Acar Department of Internal Medicine, Health Science University, Konya Research and Training Hospital, Konya, Turkey

Abstract

Objective: To determine the changes of circulating periostin levels in polycystic ovary syndrome (PCOS) and its relationship with metabolic disorders. Study Design: Cross-sectional study. Place and Duration of Study: Konya Research and Training Hospital, Turkey between September 2018 and April 2020. Methodology: Patients with PCOS were compared with healthy individuals as control. The demographics, laboratory ndings, anthropometric measurements, the levels of serum periostin and carotid intima media thickness (CIMT) were evaluated and compared. Results: There was no signi cant di erence between patients with PCOS (n = 53) and controls (n = 35), according to demographic and laboratory ndings and anthropometric measurements. The CIMT in patients with PCOS and control groups were measured as 0.5 ± 0.06 mm and 0.43 ± 0.1 mm, respectively (p <0.003). The levels of periostin in the patients with PCOS and control groups were found to be 6.43 ± 6.19 ng/mL and 3.61 ± 3.79 ng/mL, respectively (p <0.018). No statistically signi cant correlations were found according to periostin levels and metabolic variables. Conclusion: Although there was no signi cant correlation between the periostin levels and the metabolic variables in patients with PCOS as compared to those without the periostin levels, but CIMT were higher in PCOS group.

Publication Details

Page(s) 1291-1295

DOI 10.29271/jcpsp.2021.11.1291

Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 31, Issue: 11, Year: 2021

Keywords

Atherosclerosis Insulin resistance Polycystic ovary syndrome Carotid intimamedia thickness Periostin protein

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