Treatment for Symptomatic Bacterial Vaginosis: a Randomized Controlled Trial. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2017]

Author(s):

1. Nabia Tariq: Department of Obstetric Gynaecology, Shifa International Hospital, Islamabad, Pakistan

2. Ayesha Basharat: Department of Obstetric Gynaecology, Al-Nafees Medical College, Islamabad, Pakistan

3. Danish Hassan Khan: Shifa Clinical Research Centre, Shifa International Hospital, Islamabad, Pakistan

4. Ammad Fahim: Shifa Clinical Research Centre, Shifa International Hospital, Islamabad, Pakistan

5. Mohammad Hisham Khan: Shifa College of Medicine, Shifa International Hospital, Islamabad, Pakistan

Abstract:

Objective: To compare the efficacy of multiple doses of vaginal clindamycin with a single oral dose of secnidazole for the treatment of bacterial vaginosis. Study Design: Double-blinded randomized controlled trial. Place and Duration of Study: Shifa Foundation Community Health Center, from March 2012 till February 2015. Methodology: After obtaining written informed consent, a pelvic examination was performed for the confirmation of symptoms of milky white vaginal discharge on speculum examination, positive Amine test and presence of clue cells on microscopy. Pregnant women, known diabetes or any immunocompromised condition, were excluded. Blinding of the patient, doctor, and the pharmacist was done. Study cohort was then divided into two groups, Group A received medicine pack A which contained active clindamycin and placebo oral preparation, whereas group B was given pack B which contained active 2-gm secnidazole with placebo vaginal cream. Primary outcome and therapeutic success were defined by correction of two out of three (normal Nugent score, negative Amine test, and no milky white discharge) on day 15. Results: At 15th day of treatment, 96.6% participants in vaginal clindamycin group (Group A), recovered from the bacterial vaginosis; whereas, (group B) 23% patients were cured in oral secnidazole group. Conclusion: Multiple doses of vaginal clindamycin are superior to single dose of oral secnidazole for the treatment of bacterial vaginosis.

Page(s): 686-689

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 27, Issue: 11, Year: 2017

Keywords:

Bacterial vaginosis Secnidazole Intravaginal clindamycin

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