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Toxicity of sixteen pure compounds from the fruit-coat of Neem tree (Azadirachta indica A. Juss.) against Anopheles Stephensi Liston.
Author(s):
1. R. M. Tariq: Department of Zoology, University of Karachi, Karachi, Pakistan
2. S. M. N. Zafar: Department of Zoology, University of Karachi, Karachi, Pakistan
3. S. N. H. Naqvi: Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Karachi, Pakistan
4. B. S. Siddiqui: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, W.H.O. Collaborating Centre, University of Karachi, Karachi-75270, Pakistan
5. M. Rasheed: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, W.H.O. Collaborating Centre, University of Karachi, Karachi-75270, Pakistan
6. S. Faizi: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, W.H.O. Collaborating Centre, University of Karachi, Karachi-75270, Pakistan
7. M. Aslam: Department of Statistics, University of Karachi, Karachi, Pakistan
Abstract:
The toxicity of sixteen pure compounds from the fruit coat of indigenous Neem tree (Azadirachta indica.) against the 4th-instar larvae of malaria vector mosquito, Anopheles stephensi (Orangi Town wild-strain). The LC50 value of (1) azadiradione, (2) nimbocinol, (3) 173-hydroxynimbocinol, (4) azadirone, (5) deoxygedunin, (6) gedunin, (7) a-nimolactone, (8) 3­nimolactone, (9) 14,15epoxyazadiradione, (10) desfuranoazadiradione, (11) meliacinin, (12) azadironic acid, (12a) methyl ester of 12, (13) limocin-A, (14) limocin-B, (15) desfurano-6a-hydroxyazadiradione, and (16) 23,23­dihydronimocinol, (1-16) in sequence was found to be: 15, 30, 15,, 10, 150, 120, 60, 45, 18, 37, 13, 4.5, 2.8 (12a), 19, 19, 43 and 60 ppm respectively. The number 12a was the methyl ester derivative of azadironic acid and that the LC50 of standard permethrin (25 EC) was 0.120 ppm.
Page(s): 83-89
DOI: DOI not available
Published: Journal: International Journal of Biology and Biotechnology, Volume: 1, Issue: 1, Year: 2004
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