Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy | [Pakistan Journal of Medical Sciences • 2016]

Author(s):

1. Asmat Shaheen: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

2. Rubina Nazli: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

3. Sadia Fatima: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

4. Roshan Ali: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

5. Ihsanullah Khan: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

6. Salim Khattak: Institute of Basic Medical Sciences,Khyber Medical University,Peshawar, Pakistan.

Abstract:

Background and Objectives: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of preeclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women. Methods: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student's t test was performed to evaluate the mean differences in patients and control. Results: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value 36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value <0.001). Conclusion: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.

Page(s): 1419-1424

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 32, Issue: 6, Year: 2016

Keywords:

Pregnancy , Eclampsia , Visfatin , Hypertension , preeclampsia , Normotensive pregnant women

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