A rapid microwave-assisted one pot synthesis of 3, 4- dihydropyrimidin-2-(i h)-ones. | [Pakistan Journal of Science • 2016]

Author(s):

1. S. Ehsan: Department of Chemistry, Lahore College for Women University (LCWU), Lahore, Pakistan

2. B. Khan: Department of Chemistry, Lahore College for Women University (LCWU), Lahore, Pakistan

3. W. Akbar: Department of Chemistry, Lahore College for Women University (LCWU), Lahore, Pakistan

4. M. Salman: Department of polymer engineering, Punjab University, Lahore, Pakistan

Abstract:

An environmentally benign approach for one-pot synthesis of 3,4-dihydropyrimidin- 2-(1H)-ones derivative (DHPMs) using ethyl acetoacetate, urea and benzyl alcohol instead of aldehyde under microwave cavity is described. This one-pot oxidation-cyclocondensation protocol based on the Swern oxidation was performed in presence of Bi(NO3)2 without isolation of any intermediate (aldehyde) and thus reducing time, energy and raw materials with good yield of product. This study gave a new strategy of synthesis i.E by employing microwave as a tool in order to diminish reaction time and to avoid side products with increased yield and simplicity of the course of reaction. All the reported reactions were also pursued via conventional methods for a comparative study. The results obtained confirmed the superiority of the microwave irradiation method over the classical reflux heating. The compound was characterized by spectral analysis using UV, FTIR and GC-MS techniques.

Page(s): 93-96

DOI: DOI not available

Published: Journal: Pakistan Journal of Science, Volume: 68, Issue: 1, Year: 2016

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views