A Case with Neonatal-onset Type 2 Neuronal Ceroid Lipofuscinosis: A Novel Mutation | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2020]

Author(s):

1. Ozgun Uygur: Department of Pediatrics, Division of Neonatology, 0zmir Tepecik Training and Research Hospital,0zmir,Turkey

2. Mehmet Yekta Oncel: Department of Pediatrics, Division of Neonatology, 0zmir Tepecik Training and Research Hospital,0zmir,Turkey; Department of Pediatrics, Faculty of Medicine, Division of Neonatology, 0zmir Kâtip Çelebi University,0zmir,Turkey

3. Pinar Gencpinar: Department of Pediatrics, Faculty of Medicine, Division of Pediatric Neurology, 0zmir Kâtip Çelebi University,0zmir,Turkey

4. Merve Saka Guvenc: Department of Genetics, 0zmir Tepecik Training and Research Hospital,0zmir,Turkey

5. Nihal Olgac Dundar: Department of Pediatrics, Faculty of Medicine, Division of Pediatric Neurology, 0zmir Kâtip Çelebi University,0zmir,Turkey

Abstract:

Neuronal ceroid lipofuscinosis (NCL) is a lysosomal storage disorder that causes progressive neurodegenerative disease as a result of storage in neurons and other cells. Late infantile type (NCL Type 2) of NCL, which is the most common neurodegenerative disease in childhood, is characterised by a homozygous mutation in the tripeptidyl peptidase-1 (TPP-1) gene. A male infant was referred to our neonatal intensive care unit (NICU) on 26th day of life with a diagnosis of metabolic disease. He was intubated. He was hypotonic and newborn re exes were not present. Cranial magnetic resonance (MR) imaging revealed severe atrophy and delayed myelination of cerebellum and cerebral hemispheres. A novel homozygous pathological mutation was detected in exon 9 of the TPP-1 gene. With this case, it should be kept in mind that NCL may rarely start early in neonatal period and should be suspected in newborns with cerebral and cerebellar atrophy for early diagnosis.

Page(s): 543-544

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 30, Issue: 5, Year: 2020

Keywords:

Newborn , Hypotonia , Lysosomal storage diseases , Metabolic disease , Neuronal ceroid lipofuscinosis

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