Abstract:
Objective: To make comparison of the weight in grams (mean body weight, absolute renal weight and relative renal weight) of the albino rats after treatment with Lithium carbonate and L-Arginine. Design: A prospective experimental study. Place: Department of Anatomy, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre Karachi Duration: July 2007 to November 2007 Methodology: Forty five adult albino rats of either sex were taken and divided into three groups as A, B and C which were further subdivided into three subgroups according to the period of treatment they received i.e. two, four and six weeks respectively. Animals were weighed before the commencement of study. Group ‘A’ animals served as control and Group ‘B’ animals received lithium carbonate (Neurolith, Adamjee Pharma) in a dose of 20 mg/kg/day with feed. Group ‘C’ animals received lithium carbonate 20 mg/ kg/day with feed and L-Arginine (Arginine, General nutrition corporation, Pittsburg USA) 300 mg/kg/day with feed. At the end of period of treatment animals were again weighed and then sacrificed. The kidneys were removed and their weights were recorded. Results: Comparison showed an insignificant (P>0.05), significant (P 0.05), significant (P0.05) results are obtained with concomitant administration of L-Arginine with Lithium carbonate.
Page(s):
9-12
DOI:
DOI not available
Published:
Journal: Medical Channel: Journal of Modern Dental and Medical Sciences, Volume: 17, Issue: 3, Year: 2011