Wound healing effect of ethanolic extract from morning glory (Ipomoea carnea Jacq.) leaves by using different models in rats. | [Pakistan Journal of Pharmaceutical Sciences • 2018]

Author(s):

1. Rajesh Shukla: Department of Pharmaceutical Science, Suresh Gyan Vihar University,Jagatpura, Jaipur (RJ),India

2. Gaurav Gupta: Department of Pharmaceutical Science, Suresh Gyan Vihar University,Jagatpura, Jaipur (RJ),India

3. Sushil K Kashaw: Department of Pharmaceutical Sciences, Dr. HS Gour Central University,Sagar (MP),India

4. Alok Pal Jain: Department of Pharmacy, Guru Ramdas Khalsa Institute of Science & Technology,Jabalpur (MP),India

5. Santram Lodhi: Department of Pharmacy, Guru Ramdas Khalsa Institute of Science & Technology,Jabalpur (MP),India

Abstract:

Current study aims to evaluate the wound healing effect with apparent mechanism and determination of flavonoid (quercetin) from ethanol extract of Ipomea carnea jacq. leaves, family Convolvulaceae. The wound healing effect of ethanol extract from I. carnea jacq. leaves screened by excision and incision wound methods in rats. Five groups (Negative control, vehicle control, 2.5%w/w, 5% w/w ethanol extract ointment and 5%w/w Reference Ointment Povidone-iodine group) of rats (n-6) were experimentally wounded at dorsal portion of rats. The 5% w/w ointment of ethanol extract found significant wound contraction at 18-20th days, greater tensile strength, and biochemical parameters. Ethyl acetate fraction of ethanolic extract was analysed by RP-HPLC and retention time was found 3.042 min. The percentage of quercetin was found in I. carnea leaves as 0.842%. The results were supported by histopathological studies which showed augment in terms of collagen fibers, fibroblast and new blood vessels. The results were evidently exhibited the traditional uses of I. carnea leaves for wound healing effects. The healing effect may be attributed by presence of flavonoid and other compounds present in the leaves with free radical scavenging mechanism.

Page(s): 1355-1361

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 31, Issue: 4, Year: 2018

Keywords:

wound healing , histopathology , excision , Ipomoea carnea Jacq

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