Variation in Hyperbilirubinemia Levels of Male and Female Newborns in Physiological Jaundice: A Retrospective Study | [BioScientifc Review • 2023]

Author(s):

1. Ahmed Shabbir Chaudhry: Metropolitan University, Osaka, Japan

2. Muhammad Naeem Shehzad: University Institute of Medical Laboratory Science, The University of Lahore, Lahore, Pakistan

3. Maryum Akhtar: College of Life Sciences Northwest Normal University, Anning District, Lanzhou, Gansu, P.R. China

4. Muhammad Subaan Fareed: Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, W, Lanzhou, China

5. Usman Adrees: Department of Biology, Lahore Garrison University, Lahore, Pakistan

6. Muhammad Daood Khan: Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore, Pakistan

7. Hassan Shabbir Chaudhry: Department of General Medicine and Surgery, Indus Hospital, Punjab, Lahore, Pakistan.

8. Zoha Rubab: Department of Physical Therapy, Islamia University Bahawalpur, Pakistan.

9. Hafiz Ghulam Murtaza Saleem: Metropolitan University, Osaka, Japan

Abstract:

Physiological jaundice is the most common condition that requires medical attention and hospital readmission of neonates. About 60% of term and 80% of preterm babies develop jaundice in the first week of life. Furthermore, about 10% of breastfed babies stay with jaundice until the age of 1 month. In the current study, a total of 139 neonates were evaluated for physiological jaundice in which 89 (64%) were male neonates and 50 (36%) were female neonates. Blood samples were collected under aseptic conditions. All samples were performed on Roche/Hitachi COBASc, based on the spectrophotometric technique. The mean SD (15.867±5.57) was calculated for the total, direct, and indirect bilirubin in neonates who were divided into 3 groups based on the number of days, that is, 1-2, 3-5, and 6-22 days, respectively. For indirect bilirubin in the age group of 1-2, ±SD was 13.80±5.41 in males, whereas it was ±10.40 in females, while the p-value < 0.01 was significant. Hyperbilirubinemia is associated with bilirubin due to a higher mass of red blood cells. It was found that the total, direct, and indirect bilirubin significantly increased in the 1st to 5th day of life after birth with male neonates being more vulnerable to pathological jaundice as compared to female neonates.

Page(s): 1-12

DOI: 10.32350/bsr.53.05

Published: Journal: BioScientifc Review, Volume: 5, Issue: 4, Year: 2023

Keywords:

neonates , Physiological Jaundice , G6PD , Rh incompatibility

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