Zinc deficiency as severity predictor in pediatric dengue viral infection : a meta-analysis | [Pakistan Journal of Medical and Health Sciences • 2020]

Author(s):

1. Firyal Nadiah Rahmah: Faculty of Medicine,Universitas Brawijaya. Veteran Street 5 Malang,Indonesia

2. Salsabila Nabilah Rifdah: Faculty of Medicine, Airlangga University.,Airlangga Street 4 Surabaya,Indonesia

3. Ricky Indra Alfaray: Faculty of Medicine, Airlangga University.,Airlangga Street 4 Surabaya,Indonesia

4. Andry Gonius: Faculty of Medicine,Universitas Brawijaya. Veteran Street 5 Malang,Indonesia

5. Sugeng Soegijanto: Medical Faculty, Airlangga University, Tropic Medicine Department,Surabaya,Indonesia

Abstract:

Background: Endothelial cells in dengue viral infection (DVI) produce Tumor Necrosis Factor (TNF-a) in abundant number from zinc deficient patients rather than non deficient. This finding suggest zinc is protective for maintenance of endothelial cell, thus decrease the severity of dengue viral infection. Aim: In this meta-analysis, we will compare the zinc serum in deficient and non deficientpatients from several studies as predictor in dengue viral infection. Methods: We included all research articles in pediatric patients diagnosed with Dengue Fever or Dengue Hemorrhagic Fever with information on zinc serum available. Zinc deficiency is reported to be below 9,18 µmol/LThe severity is divided into dengue fever against dengue hemorrhagic fever. Result: There were 217 patients included in this study. The meta-analysis showed that there are significant difference in both results (OR 6.32 [3.50 - 11.40], p = 0.0003; I2: 84%, p < 0.00001). Conclusion: Zinc deficiency in pediatric dengue viral infection can be used for the predictor of severityin dengue viral infection. Zinc supplementation can be mandatory for dengue viral infection treatment

Page(s): 1568-1570

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 4, Year: 2020

Keywords:

Dengue fever , zinc deficiency , dengue hemorrhagic fever , Dengue viral infection

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