Urtica Dioica root extract on clinical and biochemical parameters in patients with benign prostatic Hyperplasia, randomized controlled trial | [Pakistan Journal of Biological Sciences • 2020]

Author(s):

1. Ali Akbar Karami: Institute for Prevention of Non-Communicable Diseases,Qazvin University of Medical Sciences, Qazvin, Iran

2. Mahsa Sheikhsoleimani: Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

3. Mohammad Reza Memarzadeh: Medicinal Plants Research Center of Barij, Kashan, Iran

4. Elnaz Haddadi,: Qazvin University of Medical Sciences, Qazvin, Iran

5. Mohammad Bakhshpour: Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

6. Navid Mohammadi: Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

7. Seyyed Mehdi Mirhashemi: Institute for Prevention of Non-Communicable Diseases,Qazvin University of Medical Sciences, Qazvin, Iran

Abstract:

Background and Objectives: Benign Prostatic Hyperplasia (BPH) is a common urological disorder as men get older. BPH can cause uncomfortable urinary tract symptoms. Given the high incidence of the disease, further research is an undeniable necessity for its better management. In this research, the efficacy of Urtica Dioica root extract (UDE) on clinical and biochemical parameters were evaluated in this type of patients. Materials and Methods: Participants were 60 men with BPH that randomly allocated to two equal groups (Intervention = 30 and Comparison = 30). Block balanced Randomization method was performed using a computer by a trained nurse. Intervention and comparison groups received 450 mg dayG1 UDE and placebo as tablets for 12 weeks, respectively. The main outcome was changes in International Prostate Symptoms Score (IPSS) from baseline to end of treatment. Data were collected by completing a standard questionnaire and performing relevant tests based on common laboratory methods. Results: UDE had an intermediate effect on IPSS, a small effect on serum high-sensitivity C-reactive protein (hs-CRP), intermediate to large effect on malondialdehyde (MDA) levels and intermediate effect on superoxide dismutase (SOD) activity. The magnitude of the effects of UDE on other parameters was overall negligible compared to the comparison and not significant. No side effects were seen in these patients following tablet usage. Conclusion: UDE consumption for 12 weeks among BPH patients had clinically significant effects on IPSS, serum hs-CRP, MDA and SOD activity

Page(s): 1338-1344

DOI: 10.3923/pjbs.2020.1338.1344

Published: Journal: Pakistan Journal of Biological Sciences, Volume: 23, Issue: 10, Year: 2020

Keywords:

oxidative stress , Inflammatory markers , Stinging nettle , international prostate symptom score

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