The effectiveness of 1% cysteamine, 3% tranexamic acid, 2% galactomyces ferment filtrate and 4% niacinamide application using double layering technique as a brightening agent: Chromameter and Janus-III analysis | [Journal of Pakistan Association of Dermatologists • 2024]

Author(s):

1. Anis Irawan Anwar: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

2. Siswanto Wahab: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

3. Asvina Anis Anwar: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.

4. Natalia Widjaja: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

5. Tania Azhari: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

6. Thomas Utomo: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

7. Wong Lip Wih: Lipwih Synergylab Company, Indonesia

8. Jonathan Kurnia Wijaya: Dermatology and Venereology Department, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

Abstract:

Introduction The combination of several topical agents with different vehicles or routes of administration is one of the therapeutic strategies that can be used to increase the effectiveness and possibly to reduce unwanted side-effects. Objective To assess the efficacy of 1% cysteamine, 3% tranexamic acid, 2% galactomyces ferment filtrate, and 4% niacinamide as a facial brightening agent using the double layering technique of serum and cream. Methods An open-label pre-post-test clinical trial was conducted for eight weeks using on 70 typeIV Fitzpatrick skin female participants between the ages of 31-50 years-old (mean age 37.8 years). Subjects were evaluated on a biweekly basis using chromameter and Janus-III Facial Analyzer. Results At the end of the study there was a significant L* value increase from 52.10 at W0 to 56.40 at W4 (p=0.00) along with improvement on pigmented areas from 45.52 to 43.90 after eight weeks of treatment (p=0.00 and 0.01 respectively). Conclusion Application of 1% cysteamine, 3% tranexamic acid, 2% galactomyces ferment filtrate and 4% niacinamide using double layering technique is a promising combination for facial brightness with notable reduced side-effects.

Page(s): 92-97

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 1, Year: 2024

Keywords:

Double layering , Cysteamine , Topical skin lightening agent , Skin brightness

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