Y-chromosomal deletions - A risk factor for male infertility. | [International Journal of Agriculture and Biology • 2009]

Author(s):

1. Saima Siddiqi: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan

2. Anjum Siddiq: Islamabad Clinic Serving Infertile Couples (ICSI) Center, Pak-Saudi Tower, Islamabad, Pakistan

3. Kamran Majeed: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan

4. Atika Mansoor: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan

5. Raheel Qamer: COMSATS Institute of Information Technology, Islamabad, Pakistan

6. Kehkashan Mazhar: Salma and Kafeel Medical Center, F7/4, Islamabad, Pakistan

7. Naseem Ashraf: Islamabad Clinic Serving Infertile Couples (ICSI) Center, Pak-Saudi Tower, Islamabad, Pakistan

8. Salma Kafeel: Salma and Kafeel Medical Center, F7/4, Islamabad, Pakistan

9. Azra Khanum: Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi-4600, Pakistan

10. Khalid Mehmood Khan: Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi-4600, Pakistan

Abstract:

In this study, contribution of micro-deletion towards male infertility among Pakistani male individuals has been described. Our analyses involved evaluation of seven genetic markers spanning the AZFa, b and c region among infertile males and observed micro-deletions were compared with the control healthy fertile counterparts. Data revealed AZFa deletion in 2% infertile azoospermic and oligospermic males, while the AZFb and AZFc deletions were found in 3.8 and 5.8% infertile males, respectively. These deletions were found solely in non-obstructive azoospermic patients, which consisted of 17.6% of the total non-obstructive infertile males. Our data clearly demonstrate association of Y-chromosomal micro-deletions with male infertility.

Page(s): 110-112

DOI: DOI not available

Published: Journal: International Journal of Agriculture and Biology, Volume: 11, Issue: 1, Year: 2009

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