Test ‘S’ of haplotype concordance and discordance. | [International Journal of Biology and Biotechnology • 2006]

Author(s):

1. Mahnaz Khattak: Jinnah College for Women, University of Peshawar, Peshawar, Pakistan

2. Shuhrat Shah: Department of Statistics, University of Peshawar, Peshawar, Pakistan

3. Salahuddin: Department of Statistics, University of Peshawar, Peshawar, Pakistan

Abstract:

The test presented here is based upon the proband and his/her affected as well as non-affected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, mean and variance of the test is derived under the null hypothesis of random inheritance of the disease. It is then applied to data set of varying size sibships having at least one affected and one unaffected sibs to investigate the existence of linkage disequilibrium.

Page(s): 381-386

DOI: DOI not available

Published: Journal: International Journal of Biology and Biotechnology, Volume: 3, Issue: 2, Year: 2006

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