BOT-1588: Phytosynthesis of NiO NPs using Anaphalis margaritacea and its In-vitro Pharmacological Potential | [4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025 • 2025]

Author(s):

1. Hafsa Ansar: Rawalpindi Women University Rawalpindi, Pakistan.

2. Syeda Anber Zahra: Institute of Biomaterial and Biomedical, Shanghai Zhongqiao Vocational and Technical University.,Shangai,China

3. Banzeer Ahsan Abbasi: Rawalpindi Women University Rawalpindi, Pakistan.

4. Javed Iqbal: Bacha Khan University,Charsadda, Pakistan.

5. Shazia Rehman: Rawalpindi Women University Rawalpindi, Pakistan.

6. Mamoona Munir: Rawalpindi Women University Rawalpindi, Pakistan.

7. Rabia Kazmi: Rawalpindi Women University Rawalpindi, Pakistan.

8. Zubaria Bibi: Rawalpindi Women University Rawalpindi, Pakistan.

9. F. Saeed: Rawalpindi Women University Rawalpindi, Pakistan.

10. L. Mobeen: Rawalpindi Women University Rawalpindi, Pakistan.

Abstract:

Nanotechnology deals with the synthesis of physical, chemical and biologicalsystems at scales ranging from single molecules and atoms to small sizes, andalso combining the resultant nano-materials into more complex structures. Thedevelopments generated by nanotechnology possess significant contributions inthe industrial and technological sectors involving medical, electrical,agricultural, homeland security, food safety and electronic technologies.Changes in the shape, size, surface, charge and surface area to volume ratio ofnanostructures offers NPs their distinctive characteristics that enable theirutilization in a variety of multidisciplinary areas. The current study deals withthe detailed synthesis of Anaphalis margaritacea sourced NiONPs. Thefabrication of Anaphalis margaritacea-NiONPs was confirmed via differentcharacterization techniques and analysis tools. Different biological activities likeanti-microbial, anti-oxidant and dye-degradation assay of asynthesized NiONPswas also investigated. After successful synthesis of NiONPs the biologicalapplications were performed and analyzed by utilizing different software. TheArtimia salina cytoxicity assay illustrated 77 % inhibition at 1000 µg/mL withIC50 value of 13.20 revealing good cytotoxicity potential. The A. margaritacea-NiONPs exhibited excellent bactericidal potential on almost all concentrations.The as prepared green nanoparticles showed significant dye degradationpotential (88 %). The potential antioxidant activity of A. margaritacea-NiONPsis attributed to the presence of reductones adsorbed up on the surface of ournanoparticles. The fungicidal assays for A. margaritacea-NiONPs revealedsignificant activities against selected fungal strains. On the whole, our NiONPsexhibited potential bioactivities and can be used by pharmaceutical industriesafter complete in-vivo and in-vitro trials. Moreover, the fabrication mechanismis also new frontier in research.

Page(s): 66-66

DOI: DOI not available

Published: Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025

Keywords:

antimicrobial activity , brine shrimp activity , dye degradation activity , Anaphalis margaritaceaNiONPs

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