Abstract:
Neomercazole (carbimazole) is an antithyroid drug. Present study was designed to evaluate the teratogenic and embryotoxic effects of above mentioned drug given to mice during organogenesis. The dose groups used were 0.2, 0.4, 0.6 and 0.8 μg/gBW. The pregnant mice were exposed to these dose groups on days 8 and 12 of gestation. Fetuses were recovered on day 18 of gestation and were subjected to morphological, morphometric and skeletal studies. Morphological studies revealed anomalies like distorted axis, hydrocephaly, microphthalmia, open eye lid, agnathia, micromelia, syndactyly, subcutaneous hemorrhages and kinky tail. Moreover, there was overall decline in litter size and upsurge in percentage of fetal resorptions. Detailed study of skeletal parameter presented reduction in ossification in skull, ribs and limb region.
Page(s):
251-257
DOI:
DOI not available
Published:
Journal: Biologia, Volume: 59, Issue: 2, Year: 2013