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The Anti-depressant Activity of Fixed Oil of Phaseolus vulgaris Linn. in Mice
Author(s):
1. Salma Sabir: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
2. Sadia Ghousia Baig: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
3. Muhammad Mohtasheem ul Hasan: Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
4. Afshan Siddiq: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
5. Salman Ahmed: Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
6. Syeda Anum Fatima: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
Abstract:
Phaseolus vulgaris Linn commonly known as red kidney bean, it is enriched in protein, carbohydrates and dietary fibres. Beans have nutritional and health benefits and also possess antimicrobial, antihyperglycemic, antioxidant and anticancer activity due to presence of bio-active chemical constituents. The following study was carried out to evaluate the anti-depressant activity of Phaseolus vulgaris fixed oil (PVFO) using forced swim test and tail suspension test in mice. In this study animals assigned into four groups (n=7). Group I: Control normal saline (2 mL/Kg), Group II: PVFO I (2 mL/Kg), Group III: PVFO II (4 mL/Kg) and Group IV: standard amitriptyline (10 mg/Kg). The results were significant and indicated the possible anti-depressant role of Phaseolus vulgaris fixed oil.
Page(s): 1-5
DOI: DOI not available
Published: Journal: Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences), Volume: 64, Issue: 1, Year: 2021
Keywords:
Fixed oil , beans , Phaseolus vulgaris , forced swim test , antidepressant , tail suspension test
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