Author(s):
1. Sobia Wali Muhammad:
Department of Medical Research Centre, Liaquat University of Health Sciences, Jamshoro, Pakistan
2. Muhammad Suleman Pirzado:
Department of Molecular Biology and Genetics Laboratory, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Abstract:
Objective: TTo investigate the level of interleukin-6 in alopecia areata patients. Method: The exploratory study was conducted from September to December 2021 at the Sindh Institute of Skin Disease, Karachi, and comprised alopecia areata patients regardless of age and gender in group A, while healthy controls matched for age and gender formed group B. Alopecia areata classicfiation and severity were done using the Severity of Alopecia Tool. Serum interleukin-6 was measured using enzyme-linked immune sorbent assay. Data was analysed using R statistical software v4.2.1. Results: Of the 100 subjects, 50(50%) with mean age 15.52±10.14 years were cases in group A; 26(52%) females with mean age 16.78±10.77 years, and 24(48%) males with mean age 16.44±10.3 years. The remaining 50(50%) were controls in group B. Interleukin-6 concentration was signicfiantly higher in group A ( p0.05). The concentration was the highest in patients aged 11-20 years, followed by 21-30 years, 31-40 years and 1-10 years. Conclusion: The concentration of circulatory pro-inaflmmatory interleukin-6 was signicfiantly higher in alopecia areata patients than in the healthy controls.
Page(s):
930-933
Published:
Journal: Journal of Pakistan Medical Association, Volume: 74, Issue: 5, Year: 2024
Keywords:
cytokines
,
interleukin6
,
Alopecia areata
,
Skin disease
,
Autoimmune
References:
References are not available for this document.
Citations
Citations are not available for this document.