Abstract:
Traditionally, drugs were discovered by synthesizing compounds in a time-consuming multi-step processes against a variety of in vivo biological screens. The promising candidates were investigated for their pharmacokinetic properties, metabolism and toxicity. Such a development process has resulted in high failure rates attributed to poor pharmacokinetics lack of efficacy, toxicity, adverse effects in humans and miscellaneous factors. Today, the drug discovery process has changed profoundly by the adoption of computational methods helping the design of new drug candidates more rapidly and at lower costs. Computer aided drug designing (in silico drug design) consists of a collection of tools helping to make rational decisions at different steps of the drug discovery process, such as the identification of a disease target, the selection or the design of new lead compounds and their modification to obtain better affinities followed by their synthesis, pharmacokinetic and pharmacodynamic properties. Some interesting milestones reached during an excursion between the wet and dry labs will be shared
Page(s):
0-0
DOI:
DOI not available
Published:
Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022