Abstract:
Fe (Ii). Co (II) and Ni (II) metal complexes of new Schiff bases derived from amoxicillin with sugars (D-Glucose, D) Galactose and D-Mannose) have been synthesized and characterized by elemental analysis, FTIR, electronic absorption, and atomic absorption spectroscopy, magnetic moment measurements and thermal analysis. It has been found that Schiff bases behave as bi-dentate ligands forming complexes with 1:2 (metal:ligand) stoichiometry. The complexes were neutral as confirmed by their low conductance values. The biological applications of complexes have been studied tin two gram negative (Escherichia coli and Pseudomonas aeruginosa) and two gram positive (Bacillus Subtilis and Staphylococcus aureus) microorganisms by Agar diffusion discmethod It has been found that all the complexes have higher biological activities than the pure amoxicillin.
Page(s):
440-446
DOI:
DOI not available
Published:
Journal: Journal of Chemical Society of Pakistan, Volume: 31, Issue: 3, Year: 2009