A Descriptive Study of Asthma Control in A Historical Cohort of Step 3 And 4 Asthma Patients in the Indonesian National Health Insurance Setting | [Pakistan Journal of Life and Social Sciences • 2025]

Author(s):

1. Wiwien Heru Wiyono: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, National Respiratory Center, Persahabatan Hospital,Jakarta -,Indonesia

2. Triya Damayanti: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, National Respiratory Center, Persahabatan Hospital,Jakarta -,Indonesia

3. Susanthy Djajalaksana: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Brawijaya,- Malang,Indonesia

4. Amira Permatasari Tarigan: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Sumatera Utara, Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital,Medan -,Indonesia

5. Deddy Herman: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Andalas Padang, Madina Hospital,Bukittinggi -,Indonesia

6. Cindy Patricia: GSK,Jakarta -,Indonesia

7. Fauzan Fikri: GSK,Jakarta -,Indonesia

8. Supriya K.: GSK,Jakarta -,Indonesia

9. Abhay Phansalkar: GSK,Mumbai -,India

10. Mohamed Hamouda: GSK,Dubai -,United Arab Emirates

11. Lindsey Teichman: GSK,Dubai -,United Arab Emirates

Abstract:

Asthma is a significant global health issue. Data on asthma control, particularly for moderate to moderately severe cases, is limited in Indonesia. The study aimed to assess the proportion of GINA step 3 and 4 asthmatic patients with controlled asthma (ACT score > 20) 6 to 12 months after starting ICS/LABA therapy in Indonesian National Health Insurance (JKN) hospitals. Secondary objectives included assessing patient demographics, comorbidities, clinical characteristics, exacerbation frequency, and treatment duration. A retrospective, non-interventional study was conducted using medical records from JKN hospitals (January 2014 to February 2020). The cohort was predominantly female (79.0%), with a mean age of 48.1 ± 12.97 years. At index, nearly 46% had comorbidities, including GERD (35.7%), hypertension (30.4%) and allergic rhinitis (20.9%). Approximately 67% had controlled asthma after 6 to 12 months, and the mean change in ACT score was 4.3 points (from 15.8 ± 4.35 to 19.7 ± 4.45), which is above MCID (=3).35 Specifically, 10.7% were categorized as having total control (ACT score = 25), 56.3% were well-controlled (ACT score 20-24), and 32.9% remained uncontrolled. The average treatment duration including prescription gaps was 321.8 ± 53.48 days. The findings suggest that maintenance ICS/LABA therapy is effective in managing patients with moderate to moderately severe asthma, with the majority of patients reporting control after 6 to 12 months. Nevertheless, the persistence of uncontrolled asthma in a notable subset of patients underscores the need for further research into factors affecting asthma control in this population.

Page(s): 9255-9265

DOI: 10.57239/PJLSS-2025-23.1.00725

Published: Journal: Pakistan Journal of Life and Social Sciences, Volume: 23, Issue: 1, Year: 2025

Keywords:

Asthma Control IcsLaba Therapy Gina Guidelines RealWorld Evidence Rwe Indonesian Indonesian Nationa Health Insurance Jaminan Health Insurance Jaminan

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