The Frequency of Low Serum Cortisol Level in Acute Traumatic Brain Injury | [Pakistan Journal of Neurological Surgery • 2022]

Author(s):

1. Abdul Aziz Khan: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

2. Saad Sultan: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

3. Baynazir Khan: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

4. Attiya Nasir Siddique: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

5. Aqsa Shehzadi: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

6. Mohammad Waseem: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

7. Idrees Ahmad: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

8. Sidra Asghar: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

9. Khalid Zadran: Department of Neurosurgery, Ayub Medical College and Hospital,Abbottabad,Pakistan

10. Rafia Khurshid: Department of Neurosurgery, Ayub Medical College and Hospital, Abbottabad, Pakistan

Abstract:

Objective: The study focused on evaluating the frequency of low serum cortisol levels in acute traumatic brain injury. Material and Methods: Patients with Acute Traumatic Brain Injury of both genders between the ages of 2 and 70 years old with a GCS of 12 or below were included. Information including name, age, gender, pregnancy, GCS, serum cortisol level, history of steroid use, and hypothalamic-pituitary dysfunction were all recorded on a predesigned proforma. The results were stratified among age, sex, and GCS concerning outcome variables. Results: The majority of patients (42%) ranged in age from 26 to 50. Male patients outnumbered female patients (77%). The GCS ranged between 9 and 12 in 63% of cases. Furthermore, 88 percent of patients had cortisol levels greater than 300nm/L. Hypocortisolemia was found in 13 people aged 26 to 50, 12 between the ages of 2 and 25, and only 7 between the ages of 51 and 70. There were 25 males and 7 women in the group. In 86 instances, GCS ranged from 9 to 12, while in 12 individuals, it varied from 3 to 8. Conclusion: Although the majority of patients recovered, early hypopituitarism was common in severe TBI. It is required to identify concealed pituitary dysfunction in the course of the rehabilitation process of TBI patients.

Page(s): 68-75

DOI: 10.36552/pjns.v26i1.645

Published: Journal: Pakistan Journal of Neurological Surgery, Volume: 26, Issue: 1, Year: 2022

Keywords:

cortisol , Traumatic brain injury , Hypocortisolemia

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