Toxicity Study of Infidol Colic Drop and Sennalax Administered Orally in NMRI Mice. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2018]

Author(s):

1. Saira Bano: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

2. Rabia Ali: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

3. Naeem Akhtar: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

4. Amna Qadeer: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

5. Kashifa Khanum: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

6. Muhammad Daniyal: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China; College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, China

7. Muhammad Akram: Department of Eastern Medicine, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan

8. Sultan Ayaz: Department of Eastern Medicine, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan

9. Kanwal Ahmed: Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of, Saudi Arabia

10. Khan Usmanghani: Research & Development, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Abstract:

Objective: The present study was aimed to investigate preclinical oral toxicity of Infidol colic drop and Sennalax product. Methods: NMRI strains of mice were selected for this study. Animals were divided into two groups i.e. control and treatment group (n=5/sex). Mice were treated orally using gastric gavage with doses (1 or 5 g/kg) of test product i.e. Infidol colic drops and sennalax, for 14 days and observed daily. Result: The present study demonstrated that the infidol colic drops and sennalax is potentially safe with doses of 1000 & 5000 mg/kg, as it does not cause any apparent morbidity and mortality in the animals. Conclusion: The test drug (Infidol colic drop and sennalax) could be safe because it did not show any of the side effects or toxicity on experimental animals.

Page(s): 119-123

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 6, Issue: 2, Year: 2018

Keywords:

Toxicity , infidol colic drops , sennalax

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