Abstract:
Wounds are the leading cause of death in the world. Neomycin has potential risks associated with oral administration, such as ototoxicity, nephrotoxicity, neuromuscular blocking effects, low solubility, and low bioavailability. To address this, a topical nanogel loaded with neomycin and eucalyptol was developed to improve wound healing effects. The nanogel was formulated using a solvent emulsification diffusion method. Physicochemical tests were conducted on the nanogel, including stability studies, viscosity, spreadability, extrudability, temperature swing test, centrifugation, drug content, zeta analysis, FTIR, in vitro drug release and in vivo study. The nanogel was found to have consistent pH ranging from 5 to 6, which is almost similar to pH of the skin. It had an appropriate spreadability (suitable for skin application), extrudability and consistent viscosity. The optimized formulation had a zeta potential of -8.11±6.69 mV, hydrodynamic particle size of about 328.3±38.8 nm, a low polydispersity index of about 0.134 was observed and drug content was also within the official limit. The FTIR study revealed that there were no interactions between the drugs, polymer, and additives used. In vivo study of the optimized formulation showed a promising enhanced wound healing effect in treating topical wounds compared to the marketed drug. This study demonstrates the potential of the topical nanogel formulation as an effective alternative to oral administration of neomycin for wound healing.
Page(s):
97-97
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023
Keywords:
In vivo
,
wound healing
,
neomycin
,
Topical Drug Delivery
,
Nanogel