Synthesis, spectral characterization and antiproliferative activity of new organotin(IV) dithiocarbamate compounds on K562 cells | [Pakistan Journal of Pharmaceutical Sciences • 2022]

Author(s):

1. Rapidah Mohamad: Biomedical Science Programme, Faculty of Health Sciences,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur,Malaysia

2. Normah Awang: Environmental Health and Industrial Safety Programme, Faculty of Health Sciences,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur,Malaysia

3. Nurul Farahana Kamaludin: Environmental Health and Industrial Safety Programme, Faculty of Health Sciences,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur,Malaysia

4. Nor Fadilah Rajab: Biomedical Science Programme, Faculty of Health Sciences,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur,Malaysia

5. Asmah Hamid: Biomedical Science Programme, Faculty of Health Sciences,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur,Malaysia

Abstract:

Four new organotin(IV) dithiocarbamate compounds with general formulae of PhnSn [S2CN(CH2CH2OCH2CH3)]4-n for compound 1 and 2; and PhnSn[S2CN(CH3)(CH2CH2C6H5)]4-n for compound 3 and 4 were successfully synthesized via in situ insertion method. These compounds namely, diphenyltin(IV)- [1] and triphenyltin(IV) N,N-bis(2-ethoxyethyl)dithiocarbamate [2], diphenyltin(IV)- [3] and triphenyltin(IV) N-methyl-Nphenethyldithiocarbamate [4] were each characterized with CHNS elemental analysis, FT-IR and NMR spectroscopies (1H, 13C and 119Sn). The compounds were then assessed for their cytotoxicity against K562 cells using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay upon 24 h treatment. All compounds produced the essential IR absorption bands and displayed important NCS2 peak in 13C NMR spectroscopy. From the cytotoxicity studies using MTT assay, the compounds were shown to inhibit cell proliferation in K562 leukemic cells with IC50 values ranging from 1.48 to 4.52 µM, and in the manners more cytotoxic compared to standard used imatinib.

Page(s): 865-872

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 35, Issue: 3, Year: 2022

Keywords:

Antiproliferative , cytotoxicity , and K562 cells , in situ insertion , OrganotinIV dithiocarbamate

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views