a-glucosidase and chymotrypsin inhibiting lignans from Commiphora mukul. | [Proceedings of Pakistan Academy of Sciences • 2005]

Author(s):

1. Muhammad Athar Abbasi: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

2. Viqar Uddin Ahmad: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

3. Muhammad Zubair: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

4. Shamsun Nahar Khan: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

5. Muhammad Arif Lodhi: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

6. M. Iqbal Choudhary: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Abstract:

Phytochemical investigation of the whole plant of Commiphora inukui Engl. resulted in the isolation of two lignans, epiexcelsin (1) and 5`-demethoxyepiexcelsin (2) which are reported for the first time from this species. The structure elucidation of the isolated compounds was based on 1 D and 2DNMR analysis and by the comparison with the published data. The lignans 1 and 2 showed significant inhibitory activity against α-glucosidase with the IC50 of 59.8±3.63455 µM and 75.2±8.1616 µM respectively. They also showed weak inhibitory potential against chymotrypsin with the IC50 of 110±0.025 µM and 649±0.013 µM respectively.

Page(s): 23-26

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 1, Year: 2005

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