Urinary Protein fractions in renal diseases. | [Medical Channel: Journal of Modern Dental and Medical Sciences • 2004]

Author(s):

1. Akhtar Hussain Makhdoom: Jinnah Postgraduate Medical Centre, Karachi, Pakistan

2. Khem A. Karira: Jinnah Postgraduate Medical Centre, Karachi, Pakistan

3. Mujtaba Farooq Rana: Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Abstract:

BACKGROUND: The prevalence of chronic renal disease is increasing worldwide as also in Pakistan. Overt proteinuria might not be merely a marker of glomerular dysfunction, since there is abundant experimental evidence that abnormal amounts of filtered protein have a role in progression of disease. OBJECTIVE: The present study proposes to define proteinuria in normal and different groups of renal disease and to establish the pattern of urinary protein fractions in these groups. METHODS: Fifty nine patients and twenty one control subjects were selected for the study. The subjects were evaluated for renal function assessment and their urinary protein fractions were estimated by electrophoresis. RESULTS: In renal disease cases total 24 hours urinary protein excretion was significantly high. Albumin. and gamma globulin were the major protein fractions excreted by renal disease patients. Albumin and alpha II excretion by nephrotic syndrome patients was significantly higher (p

Page(s): 31-34

DOI: DOI not available

Published: Journal: Medical Channel: Journal of Modern Dental and Medical Sciences, Volume: 10, Issue: 3, Year: 2004

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