The role of Hippophae rhamnoides L. on 5-fluorouracil-ınduced oral mucositis in rats | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Muhammet Dilber: Dilber ENT & Aesthetic Clinic, Istanbul, Turkey

2. Bahadir Suleyman: Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

3. Renad Mammadov: Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

4. Zeynep Suleyman: Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

5. Bulent Yavuzer: Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

6. Mine Gulaboglu: Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey

7. Ertugrul Erhan: Department of Otorhinolaryngology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

8. Ismail Salcan: Department of Otorhinolaryngology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

9. Halis Suleyman: Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey

Abstract:

Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). The 5-FU was injected in the FUG group intraperitoneally. The HRFU was injected 5-FU at 100mg/kg IP one hour after the 50mg/kg HRE was given orally. Olive oil was used as a solvent for the HG. HRE was given to the rats three times a day for ten days. 5-FU was given one dose on the 1st, 3rd and 5th days. On the 10th day, the tissues removed from the animals were euthanized with high-dose anaesthesia and were macroscopically examined. The levels of the oxidant, antioxidant and proinflammatory cytokines were investigated.It was seen that HRE alleviated the symptoms of severe mucositis by antagonizing the effects of 5-FU on oxidant, antioxidant and proinflammatory cytokines such as malondialdehyde, total glutathione, superoxide dismutase, catalase, nuclear factor kappa-B and interleukin-6 in inner cheek and tongue tissue. These results recommend that HRE may be benefical in the cure of 5-FU-associated oral mucositis.

Page(s): 1443-1449

DOI: 10.36721/PJPS.2023.36.5.REG.1443-1449.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: 5, Year: 2023

Keywords:

5fluorouracil , Rats , oral mucositis , Hippophae rhamnoides L , oxidative and inflammatory

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