Wound healing activity of Hymenocallis littoralis - moving beyond ornamental plant. | [Pakistan Journal of Pharmaceutical Sciences • 2018]

Author(s):

1. Sreeramanan Subramaniam: School of Biological Sciences, Universiti Sains Malaysia,Minden, Penang,Malaysia

2. Ong Ming Thong: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia,Minden, Penang,Malaysia

3. Lam Kit Lay: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia,Minden, Penang,Malaysia

4. Vikneswaran Murugaiyah: School of Pharmaceutical Sciences Universiti Sains Malaysia,Minden, Penang,Malaysia

5. Geethaa Sahgal: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia,Minden, Penang,Malaysia

6. Jeevandran Sundarasekar: School of Biological Sciences, Universiti Sains Malaysia,Minden, Penang,Malaysia

Abstract:

Spider lily (Hymenocallis littoralis) belongs to Amaryllidaceae family is a well-known plant species for its medicinal properties. The inhibitory effects of H. littoralis methanol sonication extracts were evaluated for wound healing activity. This is the first report on the wound healing activity of Malaysian origin H. littoralis. The bulb, flower, root, anther, stem and leaves of H. littoralis methanol sonication extracts were used for scratch-wound assay. The cell line was treated with two different concentrations; 1 and 10µg/ml of extracts. The extracts were prepared freshly by dissolving in sterile phosphate saline buffer (PBS) and the healing activity was observed from 2, 4, 8, 12, 24, 36 and 48 h. The bulb, root, stem and anther methanol extracts demonstrated active wound healing activities at 1 µg mL-1at 36 h of treatment. At the low concentration the bulb, root, stem and anther methanol extracts heals the wound compared to leaf and flower extracts. It's demonstrated that these extracts contain effective phytochemical substances which are responsible for wound healing process. This finding suggests the potential application of H. littoralis methanol extract in wound healing activity.

Page(s): 2537-2543

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 31, Issue: 6, Year: 2018

Keywords:

root , Hs27 cell line , Hymenocallis littoralis , Methanol sonication

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