Therapeutic potential and biological investigation of golden seal root (Hydrastis canadensis L.) powder for the management of hyperuricemia | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Muhammad Muqaddas Mustafai: Quaid-e-Azam Medical College,Bahawalpur,Pakistan

2. Aalia Saeed: Quaid-e-Azam Medical College,Bahawalpur,Pakistan

3. Farkhanda Kanwal: Sheikh Zayed Medical College, Rahim Yar Khan, Pakistan

4. Ihteshamul Haq: Department of Biotechnology and Genetic Engineering, Hazara University,Mansehra,Pakistan

5. Hina Mahreen: Department of Zoology, The Women University,Multan,Pakistan

6. Tasleem Kausar: Department of Zoology, Government Sadiq College Woman University Bahawalpur, Pakistan.

7. Mahwan ur Riaz: Department of Biotechnology, Islamic International University,Islamabad,Pakistan

8. Saeedah Musaed Almutairi: Department of Botany and Microbiology, College of Science, King Saud University,Riyadh,Saudi Arabia

9. Mohamed S Elshikh: Department of Botany and Microbiology, College of Science, King Saud University,Riyadh,Saudi Arabia

10. Dina S Hussein: Department of Chemistry, College of Sciences and Health, Cleveland State University,Cleveland,USA

Abstract:

Elevated uric acid levels are termed uricemia. Uric acid is the end product of protein or more specifically purine metabolism. Many medicinal and naturally existing remedies are used to reduce elevated uric acid levels. Goldenseal root is an important medicinal plant used by native Americans. This study investigated the therapeutic potential of goldenseal powder against hyperuricemia. In this study, sixty females with elevated uric acid levels were enrolled and were divided into three groups; control group (Go) and treatment group G1 and G2. Treatment groups were given different doses of goldenseal root powder. Serum uric acid levels were measured before and after the trial. Chemical characterization and phytochemical analysis were also performed. 23.87±1.24% moisture is present in goldenseal root powder. 12.62±0.13% ash is present in goldenseal root while 22.81±0.09% of carbohydrates were present in goldenseal root. 12.89±0.08%, 12.72±0.57%, and 15.61±0.02% of crude protein, crude fat and crude fiber are present in goldenseal root powder. Goldenseal root powder carried a significant amount of TPC and TFC depicted in fig. 1. Total phenolic content (TPC) was 514.27±0.02 ug GAE/ ml and total flavonoid content (TFC) was 334.87±0.11 ug CE/ml. Two sample t-tests showed a significant reduction in uric acid levels when goldenseal root powder was given to subjects. All data was taken significantly at p<0.05.

Page(s): 307-310

DOI: 10.36721/PJPS.2023.36.1.SP.307-310.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: S1, Year: 2023

Keywords:

Flavonoids , hyperuricemia , Phytochemicals , Goldenseal root , Hydrastis canadensis , Uricemia

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