Synthesis, spectral analysis and biological evaluation of N- alkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives. | [Pakistan Journal of Pharmaceutical Sciences • 2016]

Author(s):

1. Aziz-Ur-Rehman : Department of Chemistry, Government College University, Lahore, Pakistan

2. Muhammad Athar Abbasi: Department of Chemistry, Government College University, Lahore, Pakistan

3. Sabahat Zahra Siddiqui: Department of Chemistry, Government College University, Lahore, Pakistan

4. Ayesha Mohyuddin: Department of Chemistry, School of Science and Technology, University of Management and Technology, Lahore, Pakistan

5. Sohail Nadeem: Department of Chemistry, School of Science and Technology, University of Management and Technology, Lahore, Pakistan

6. Syed Adnan Ali Shah: Atta-ur-Rahman Institute for Natural Products Discovery AuRIns, Level 9, FF3, University Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Faculty of Pharmacy, University Technology MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia

Abstract:

New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines (2a-F) with 4-chlorobenzensulfonyl chloride (1) to yield N-alkyl/aryl-4-chlorobenzenesulfonamide(3af)that was then derivatized by gearing up with ethyl iodide (4), benzyl chloride (5) and 4-chlorobenzyl chloride (6) using sodium hydride as base to initialize the reaction in a polar aprotic solvent (DMF) to synthesize the derivatives, 7a-F, 8af and 9a-F respectively. Structure elucidation was brought about by IR, 1H-NMR and EIMS spectra for all the synthesized molecules which were evaluated for their antibacterial activities and inhibitory potentials for certain enzymes.

Page(s): 1489-1496

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 29, Issue: 5, Year: 2016

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