An Economical Non-Antibiotic Alternative to Antibiotic Therapy for Subclinical Mastitis in Cows | [Pakistan Veterinary Journal • 2021]

Author(s):

1. Misbah Ijaz: Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture,Faisalabad,Pakistan

2. Asad Manzoor: Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan

3. Muhammad Tahir Mohy-ud-Din: Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture,Faisalabad,Pakistan

4. Faiza Hassan: Institute of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture,Faisalabad,Pakistan

5. Zia Mohy-ud-Din: Department of Theriogenology, Faculty of Veterinary Science, University of Agriculture,Faisalabad, Pakistan

6. Muhammad Ans: Department of Pharmacology, Lahore Medical & Dental College,Lahore,Pakistan

7. Muhammad Ijaz Saleem: Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture,Faisalabad,Pakistan

8. Hamza Hassan Khan: Department of Theriogenology, Faculty of Veterinary Science, University of Agriculture,Faisalabad, Pakistan

9. Fakhra Khanum: Department of Nutrition and Dietetics, The University of Faisalabad,Faisalabad,Pakistan

Abstract:

mportance of mastitis and antibiotic resistance is dictating to search non-antibiotic alternatives for the therapy. Trisodium citrate (TSC) being buffer system of the glandular tissue and, vitamin C (Vit. C), zinc and copper being important ingredients required for functioning of immune system fancy chances for a suitable alternative mastitis therapy. The current study was planned to evaluate therapeutic efficacy and cost effectiveness of these ingredients in subclinical mastitis. For this purpose, 40 sub-clinically mastitis cows were randomly divided into 2 equal groups. Group T1 was treated orally with TSC, Vit. C, ZnSo4 and CuSo4, while group T2 was treated with standard antibiotic therapy. Milk pH significantly (P<0.05) differed between the two treatments till day 7th post-initiation of treatment when T1 restored the pH values within normal range earlier than T2. A non-significant (P>0.05) difference was observed in milk pH, fat, lactose, proteins, TS, SNFs, somatic cell counts and restoration of milk yield between the two treatments indicting comparable efficacy. A statistically significant (P<0.05) difference was observed in serum Cu and Zn levels indicating that the supplementation of Cu and Zn led to higher serum values in animals of T1. The use of non-antibiotic oral formulations as mastitis therapy resulted in a net profit of Rs. 457/animal/day. The oral non-antibiotic antibacterial formulation is a therapeutically and economically suitable alternative to rational antibiotic-based therapy to treat subclinical mastitis in dairy cows.

Page(s): 475-480

DOI: 10.29261/pakvetj/2021.059

Published: Journal: Pakistan Veterinary Journal, Volume: 41, Issue: 4, Year: 2021

Keywords:

Mastitis , Milk , Antibiotic resistance , Cost effectiveness , Nonantibiotic alternatives

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