Use of systemic steroids during pulmonary exacerbations in children and adolescent with Cystic fibrosis | [Journal of Pakistan Medical Association • 2022]

Author(s):

1. Danish Abdul Aziz: Department of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.

2. Fatima Siddique: Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan

3. Shahira Shahid: Department of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.

4. Anusha Alam: Fourth Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan.

5. Namrah Aziz: Second Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan.

Abstract:

Objective: To determine the role of systemic steroids in cystic fibrosis patients and its effects on pulmonary exacerbation in children and adolescents. Method: The retrospective cohort study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from January 2015 to December 2019 of cystic fibrosis patients aged 3-18 years hospitalised with pulmonary exacerbations. The patients were divided into systemic steroid group A and non-systemic steroid group B. Patients in group A received parenteral steroids during acute exacerbation of cystic fibrosis in the first two weeks of admission, while those in group B did not receive systemic steroids. Length of hospital stay and number of days on oxygen support were compared between the groups. Data was analysed using SPSS 22. Result: Of the 124 patient charts evaluated, 84(67.7%) were included; 40(47.6%) in group A and 44(52.4%) in group B. There were no significant differences between the groups related to age, age at diagnosis, weight, height, and pulmonary exacerbations (p>0.05). Group A had significantly fewer days on oxygen support compared to group B (p<0.001), but there was inter-group difference in mean length of hospital stay (p=0.53). Conclusion: Systemic steroid usage during hospitalisation for acute exacerbation of cystic fibrosis was associated with decreased duration of oxygen requirement with standard treatment.

Page(s): 1525-1528

DOI: 10.47391/JPMA.3729

Published: Journal: Journal of Pakistan Medical Association, Volume: 72, Issue: 8, Year: 2022

Keywords:

Pulmonary exacerbation , Systemic corticosteroids , Oxygen support

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