Abstract:
To study the relationship of Vitamin d deficiency and some minerals metabolism in the children with sickle cell disease (SCD) in the city of Jeddah, western region of Saudi Arabia. Measuring the concentration of serum 25 (OH) Vitamin D, calcium, phosphorus and magnesium in children with SCD aged between newborn to 12 years old. A total of 51 children with sickle cell disease (both gender) included 28 males (54.9%) and 23 females (45.1%) aged between newborn and 12 years old and 70 healthy matching controls were admitted or visited sickle cell section in the Maternity and Children Hospital in the city of Jeddah. Fasting blood samples were collected and the serum was separated and stored at -30ºC until the time of analysis. Serum 25 (OH) vitamin D was determined using a commercially available kit (VDBP,Gc globulin), calcium, phosphorus and magnesium were measured using a clinical auto analyser. The patients were divided into two groups according to the ages. Group-A included 21 patients (both gender) aged between newborn and 6 years, group-B included 30 patients (both gender) aged between 7-12 years. The results obtained showed that the serum concentrations of 25(OH) Vitamin D in both patients groups were significantly lower than the healthy matching controls (P+2 was significantly lower in patients than the controls (P0.05) and significantly higher in the serum magnesium of group-B (P+2 in the nature of erythrocyte membrane in sickle cell patients.
Page(s):
295-299
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Medical Sciences, Volume: 19, Issue: 4, Year: 2003