The effect of hypercholesterolemia on serum vascular endothelial growth factor and nitrite concentrations in early stage of atherosclerosis in Rabbits. | [Pakistan Journal of Nutrition • 2009]

Author(s):

1. Shaghayegh Haghjooyjavanmard: Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2. Mehdi Nematbakhsh: Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3. Masoud Soleimani: Department of Haematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract:

Vascular Endothelial Growth Factor (VEGF) and Nitric Oxide (NO) play an important role for maintaining endothelial integrity. The purpose is to investigate the VEGF alteration during early atherosclerosis lesion formation in an animal model of hypercholesterolemia. We also measured nitrite to observe the relationship between VEGF and endothelial NO production. 20 white male rabbits randomly assigned in 2 groups (1% high-cholesterol diet, HC group, n = 14, or standard diet, control, n = 6) for 4 weeks. The serum levels of VEGF and nitrite (NO metabolite) were determined. Fatty streaks were measured in rabbit’s aortas. The results indicated that the serum level of VEGF concentration was significantly higher in hypercholesterolemic rabbits and negatively correlated with fatty streak lesions (r = -0.89, p

Page(s): 86-89

DOI: DOI not available

Published: Journal: Pakistan Journal of Nutrition, Volume: 8, Issue: 1, Year: 2009

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