Whole Genome Sequencing of Carbapenem-Resistant Acinetobacter baumannii: Systematic literature review | [Rawal Medical Journal • 2025]

Author(s):

1. Hafsa Waseem: Departments of Microbiology, Watim Medical & Dental College, Rawalpindi, Pakistan

2. Ihsan Ullah: Khyber Medical College, Peshawar, Pakistan

3. Nazish Babar: Gajju Khan Medical College, Swabi, Pakistan

4. Momena Ali: Khyber Medical College, Peshawar, Pakistan

5. Nehaj Tariq: Departments of Microbiology, Watim Medical & Dental College, Rawalpindi, Pakistan

6. Afnan Naeem: Army Medical College, Rawalpindi, Pakistan

Abstract:

Objective: To comprehensively examine the existing literature concerning the application of Whole genome sequencing in deciphering the genomic landscape of Carbapenem Resistant Acinetobacter baumannii (CRAB). Methodology: The systematic search was conducted across multiple databases, including PubMed, Scopus and Web of Science focusing on genomics and antimicrobial resistance. Results: The review synthesizes a broad spectrum of research studies, encompassing investigations into the genetic determinants, evolutionary patterns, and dissemination mechanisms of carbapenem resistance in A. baumannii strains worldwide. It endeavors to delineate identified resistance genes, mutations, mobile genetic elements, and their roles in the persistence and dissemination of resistance traits within A. baumannii populations. Conclusion: The systematic analysis serves as a valuable compendium, offering critical insights into the intricate interplay of genetic elements driving antimicrobial resistance. This, in turn, contributes to the global endeavors aimed at combating CRAB and advancing strategies for effective antibiotic stewardship.

Page(s): 251-255

DOI: DOI not available

Published: Journal: Rawal Medical Journal, Volume: 50, Issue: 1, Year: 2025

Keywords:

infections , Carbapenemresistant Acinetobacter baumannii CRAB , Wholegenome sequencing WGS , Antimicrobial resistance

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