An environment friendly procedure for the synthesis of potent biologically active compounds containing 4-thiazolidinone. | [Journal of Chemical Society of Pakistan • 2008]

Author(s):

1. Muhammad Naeem: College of Earth and Environmental Sciences, University of the Punjab, Lahore, Pakistan

2. Muhammad Nawaz Ch: College of Earth and Environmental Sciences, University of the Punjab, Lahore, Pakistan

3. Iftikhar Bloch: College of Earth and Environmental Sciences, University of the Punjab, Lahore, Pakistan

4. Salma Rehman: Pakistan Council of Scientific and Industrial Research (PCSIR), Labs Complex, Ferozepur Road, Lahore, Pakistan

Abstract:

A series of compounds N-(R)-2-(4-thiazolidinone) acetamide and (2Z)-2-[R, imino]-3-[(4-thiazolidinone) acetyl]-I, 3-thiazolidin-4-one containing thiazolidinone as basic nucleus were synthesized and found that the synthetic route is environment friendly. Microwave irradiation was used for the activation and montmorillonite clay K-10 was used as a catalyst. Chromatographic techniques were used for purification and separation. The structural elucidation was conducted by spectroscopic means (FTIR, NMR and MS). Diffusion method was used to assess the antibacterial activity and compounds 1a, 2a, 2c and 2e were shown to have the best antibacterial activity.

Page(s): 780-784

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 30, Issue: 5, Year: 2008

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