Abstract:
The vgf gene (non-acronymic) is highly conserved and was identified based on its rapid induction in vitro by nerve growth factor, although subsequently this can be induced by brain-derived neurotrophic factor, and glial derived growth factor. The vgf gene gives rise to a 68kDa precursor polypeptide, which is robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific prohormone convertases in these cells results in the production of a number of smaller peptides. The vgf gene and peptides are widely expressed through the brain particularly in the hypothalamus and hippocampus and are associated with a number of neuroendocrine roles. Here, we will review the roles of VGF gene and its peptides in the regulation of energy expenditure and beyond.
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Published:
Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023