Use of Avicel and spray dried Lactose in the development of Levofloxacin 250mg tablets by direct compression method. | [Pakistan Journal of Pharmacology • 2005]

Author(s):

1. Rabia Ismail Yousuf: Department of Pharmaceutical Sciences, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

2. Muhammad Harris Shoaib: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

3. Syed Ayub Ali: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

4. N. Haque: Department of Pharmacy, Balochistan University, Quetta, Pakistan

Abstract:

In present study a formulation of Levofloxacin tablet 250mg was prepared by direct compression method, using two directly compressible excepients, i.e Avicel PHIOI (62.5mg) and spray dried lactose (62.5mg) with magnesium stearate(5mg) as lubricant glidant on Erweka single punch machine. These tablets are round in shape having mean weight of 373.55 ± 8.463mg with mean diameter and thickness of 12.3 ± 0.03mm and 2.4 ± 0.11 mm. The hardness of the tablets was 12 ± 0.39kg. Friability of tablets were 0.67% using Roche friabilator and disintegration time was 10 min in Erweka basket rack assembly. Dissolution test was performed on USP apparatus-I and % Q was found to be 94.59. Assay results was 100.54% when performed by HPLC technique using C18 column. This formulation gives excellent results using minimal excepient and simple manufacturing procedure. This type of work gives direction to try to make formulation simple and cost effective. As direct compression method is not cheap in terms of raw materials but also produces batch in short period of time. Moreover considering biopharmaceutical aspects, tablet manufactured by direct compression dissolved rapidly in gastrointestinal tract due to prime particle dissociation as compared to that of wet granulation method.

Page(s): 67-74

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmacology, Volume: 22, Issue: 2, Year: 2005

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